Effects of metoprolol succinate sustained-release tablets on pulse wave velocity in patients with essential hypertension

Abstract

Objective To evaluate the effects of metoprolol succinate sustained-release tablets on Brachial-ankle pulse wave velocity(baPWV) in patients with essential hypertension.Methods The levels of serum blood lipid and blood glucose,blood pressure,heart rate and baPWV were measured respectively in twenty-eight patients with essential hypertension and twenty-eight healthy persons with normal blood pressure.After twelve weeks treated with metoprolol succinate sustained-release tablets,The blood pressure and baPWV were measured again and were studied in patients with essential hypertension.Results The systolic blood pressure (156.3 ±8.6) mm Hg vs (112.6 ± 11.9) mm Hg,diastolic blood pressure (103.6 ± 6.7) mm Hg vs (68.2 ± 8.9) mm Hg and baPWV(1971.3 ± 187.4)cm/s vs(1187.2 ± 198.5)cm/s in patients with essential hypertension were higher than that of healthy persons with normal blood pressure significantly(P ＜ 0.05),The heart rate (85.2 ±4.7) vs (64.5 ± 6.3) beat/min,systolic blood pressure (156.3 ± 8.6) mm Hg vs (121.9 ± 7.9) mm Hg,diastolic blood pressure(103.6 ± 6.7) mm Hg vs (76.3 ± 5.1) mm Hg and baPWV (1971.3 ± 187.4) cm/s vs (1236.5 ± 186.3)cm/s were decreased significantly in patients with essential hypertension(P ＜ 0.05)after treated with metoprolol succinate sustained-release tablets.Conclusion Metoprolol succinate sustained-release tablets treated in patients with essential hypertension can decreased pulse wave velocity,impore elasticity of large arterise and increase the distensibility of aorta. Key words: Hypertension; Pulse wave velocity; Metoprolol succinate sustained-release tablets