The clinical analysis of levamlodipine besylate combined with benazepril in treatment of primary hypertension with left ventricular hypertrophy

Abstract

Objective To observe the effect of levamlodipine besylate combined with benazepril in treatment of primary hypertension with left ventricular hypertophy.Methods Ninety-eight primary hypertension with left ventricular hypertrophy patients were divided into two groups by random number table.Observation group(49 cases) was treated with levamlodipine besylate combined with benazepril,and control group (49 cases) was only treated with levamlodipine besylate.The clinical effect,the levels of systolic blood pressure (SBP),diastolic blood pressure (DBP),left ventricular posterior wall (LVPW),interventricular septal thickness (IVST),left ventricular end-diastolic dimension (LVEDD) and left ventricular mass index (LVMI) were compared between two groups.Results The total effective rate in observation group was 93.9％ ( 46/49 ),which was significantly higher than that in control group (77.6％,38/49 ) ( x2 =5.333,P ＜0.05).Before treatment,the differences were not statistically significant in the levels of SBP and DBP (P ＞0.05).After treatment,the levels of SBP,DBP,LVPW,IVST,LVEDD and LVMI were significantly decreased in both groups (P＜0.05).Moreover,the levels of SBP,DBP,LVPW,IVST,LVEDD and LVMI in observation group after treatment were significantly lower than those in control group[ ( 121.27 ± 8.69 ) mmHg( 1 mm Hg =0.133 kPa) vs.( 131.54 ± 9.85 ) mm Hg,( 82.45 ± 4.69 ) mm Hg vs.( 88.49 ± 5.14 ) mmHg,(9.42 ± 1.58 ) mm vs.( 11.41 ± 1.92 ) mm,(9.56 ± 1.31 )mm vs.( 11.38 ± 1.85 ) mm,(47.86 ± 2.38 ) mm vs.(51.46 ±3.25) mm,(108.16 ±6.24) g/m2 vs.(119.21 ±7.68) g/m2] (P ＜0.05).Conclusion Levamlodipine besylate combined with benazepril in treatment of primary hypertension with left ventricular hypertrophy can improve the clinical effects and ease left ventricular hypertrophy status,which can be applied in clinic. Key words: Amlodipine; Hypertension; Cardiomegaly; Benazepril