The clinical efficacy of Danhong injection for the treatment of idiopathic pulmonary fibrosis

Abstract

Objective To study the clinical efficacy of Danhong injection for the treatment of idiopathic pul-monary fibrosis.Methods 84 patients with idiopathic pulmonary fibrosis were randomized into the control group （ prednisone treatment） and the observation group （ based on the prednisone treatment, added the Danhong injec-tion）,42 patients per group.The clinical efficacy,oxygen partial pressure and CO diffusing capacity,the TGF-β1 in the serum and pulmonary ventilation in the two groups were observed and compared after 6-week treatment. Results Compared with the control group, the total effective rate was significantly increased （ 92.9% vs 71.4%） in the observed group（P〈0.05）;compared with the control group,the oxygen partial pressure [（67.57 ±9.93） vs （51.74 ±9.21）]mmHg and CO diffusing capacity[（18.98 ±3.44） vs （15.83 ±3.06）]mL/（min· mmHg） were obviously increased in the observed group after treatment（ P〈0.05）;compared with the control group,the content of TGF-β1 in the serum was significantly reduced [（1.15 ±0.13） vs （3.02 ±0.28）]μg/L and the pulmonary ventila-tion [（1.85 ±0.36） vs （1.69 ±0.30）]L was obviously increased in the observed group after treatment（P〈0.05）;compared with the control group,the incidence of adverse reactions was obviously reduced （4.8%vs 19.0%） in the observed group（P〈0.05）.Conclusion The treatment of Danhong injection for the idiopathic pulmonary fibrosis has the significant efficacy and high safety,can effectively correct th hypoxemia,significantly improve the lung function, which is worthy of clinical promotion. Key words: Idiopathic pulmonary fibrosis; Danhong injection