Synthesis New Liquid Electrodes for Determination Lansoprzole Based on a Molecularly Imprinted Polymer

Abstract

Liquid electrodes of Lansoprazole (LP) imprinted polymer was synthesis based on precipitation polymerization mechanism. The molecularly imprinted (MIP) and non-imprinted (NIP) polymers were synthesized using LP as a template. By methyl methacrylate (MMA) as a monomer, Pentaerythritol tetraacrylate (PTA) and ethylene glycol dimethacrylate (EGDMA) as cross-linkers and benzoyl peroxide (BP) as an initiator. The molecularly imprinted membranes were synthesized using Dimethyl adipate (DMA), Dibutyl phthalate (DBPH), Dioctyl phthalate(DOPH), and Nitrobenzene (NB) as plasticizers in PVC matrix. The slopes and limit of detection of liquid electrodes obtained from the calibration curves ranged from (-17.85– -20.89) mV/decade and 1.8 x 10-5–6.0 x 10-6 M, respectively, and the response time was about 60 seconds. The Liquid electrodes were filled with 10-2 M standard solution of the drug and observed stable response for a pH ranged from 2.0 to 11.0 and with good selectivity for over several species. The fresh electrodes of synthesis were effectively used in the pharmaceutical sample to determine LP without any time-consuming pretreatment measures.