Abstract
Liquid electrodes of domperidone maleate (DOMP) imprinted polymer were synthesis based on precipitation polymerization mechanism. The molecularly imprinted (MIP) and non-imprinted (NIP) polymers were synthesized using DOMP as a template. By methyl methacrylate (MMA) as monomer, N,Nmethylenebisacrylamide (NMAA) and ethylene glycol dimethacrylate (EGDMA) as cross-linkers and benzoyl peroxide (BP) as an initiator. The molecularly imprinted membranes were synthesis using acetophenone (APH), di-butyl sabacate (DBS), Di octylphthalate (DOPH) and triolyl phosphate (TP)as plasticizers in PVC matrix. The slopes and limit of detection of liquid electrodes obtained from the calibration curves ranged from (-18.88– -29.01) mV/decade and (4.0 × 10-5 – 6.0 × 10-5) M, respectively and the response time was about 60 seconds. The Liquid electrodes were filled with (10-2 M) standard solution of the drug and observed stable response for a pH ranged from 2.0 to 11.0 and with good selectivity for over several species. The fresh electrodes of synthesis were effectively used in the pharmaceutical sample to determine DOMP without any time consuming pretreatment measures.
Highlights
Molecularly impressed polymers (MIPs) are a promising solution to tailor-made binding receptor locations by rearranging templates and rearranging functional monomers Functional monomers and cross linkers involving the formation of cavities in which the model is placed in the presence of template molecules
The results indicate that the response time of the electrodes were approximately 25.2 seconds for the solution of Domperidone at high concentration 10-2M and about 59 seconds at low concentration10-5M
Preparation solutions of Domperidone concentrations 1×10-3 and 1×10-4 M. using membrane IQ based on di-butyl sabacate (DBS) and IIIQ based on Di octylphthalate (DOPH) as plasticizer
Summary
Impressed polymers (MIPs) are a promising solution to tailor-made binding receptor locations by rearranging templates and rearranging functional monomers Functional monomers and cross linkers involving the formation of cavities in which the model is placed in the presence of template molecules. Domperidone molecularly imprinted polymer (DOMP.-MIP1) were achieved by mixed , the template (DOMP) 0.23mmol (0.1g) was dissolved in 5 mL of DMF in a thick walled glass tube. A functional monomer methylmethacrilate (MMA) 11.6 mmol (1g), cross-linker N,Nmethylenebisacrylamide (NMAA) 3.25 mmol (1.5g) and initiator (BPO) 0.09 mmol (0.024g), and the seconddomperidone molecularly imprinted polymer (DOMP.-MIP2) were achieved by mixed , the template (DOMP) 0.997 mmol (0.425g) was dissolved in 5 mL of DMF in a thick walled glass tube. Experimental results of synthesis of molecularly imprinted (MIP) and non-imprinted polymers (NIP) based on monomer MMA and cross linker (NMAA). The plasticizer is an essential part of the sensing membrane which have important role as a solvent for the different components and determines the mobility of the analyze in membrane Both of the plasticizers that are used, APH and DBS, are suitable for the fabrication of MIP-based DOMP electrodes. Electrode specification findings were acquired from the calibration curves mentioned in (Table 1)
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