Abstract
This study was aimed four electrodes were synthesized based on molecularly imprinted polymers (MIPs). Two MIPs were prepared by using bromhexine hydrochloride (BHH) as the template, acryl amide (AA) and methyl methacrylate (MMA) as monomers as well as ethylene glycol dimethacrylate (EGDMA) and penta erythritol triacrylate (PETA) as cross linkers respectively and benzoyl peroxide as initiator. The same composition was used in preparation of non-imprinted polymers (NIPs), but without the template (Bromhexine hydrochloride). To prepare the membranes, different plasticizers were used in PVC matrix such as: Di butyl sebacate (DBS), acetophenone (AP), di-octyl phthalate (DOPH) and tri-2-ethyl hexyl phosphate (TEHP). The characteristics studied are the slop, detection limit, life time and linearity range of BHH–MIPs electrodes. Results obtained of selectivity measurements on interfering cations (Al+3, Ca+2, K+) and some pharmaceutical additives such as methylparaben, propylparaben, trisodium citrate show that no interfering with drug bromhexine hydrochloride. The preparation electrodes have been shown good response including testing pharmaceutical analysis.
Highlights
Bromhexine hydrochloride membranes selective electrodes can be constructed by mixing with different plasticizers
These plasticizers di butyl sebacate (DBS), ACPH, di-octyl phthalate (DOPH) and tri-2-ethyl hexyl phosphate (TEHP) were used to prepared bromhexine hydrochloride membranes electrodes based on PVC
Liquid selective electrodes for warfarin sodium based on poly matrix membrane
Summary
Bromhexine hydrochloride is a mucolytic agent that reduces sputum thickness, and works by breaking down mucus so it is easier to cough out. It helps patients breathe deeply, and is used to treat abnormal mucus secretions, including influenza, respiratory tract infections, and the common cold. In an overthe-counter form, bromhexine hydrochloride is used to treat cheat congestions and coughs (6). Bromhexine hydrochloride’s side effects include rash, diarrhea, vomiting, nausea, and pain in the upper stomach. This medication should not be used by pregnant or breastfeeding women.
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