Preparation of New Molecularly Imprinted Polymers and its Use in the Selective Extraction For Determination Phenylephrine Hydrochloride at Pharmaceuticals

Abstract

This study was aimed at four electrodes were synthesized based on molecularly imprinted polymers (MIPs). Two MIPs were prepared by using phenylephrine hydrochloride (PPH) as the template, methyl methacrylate (MMA) as monomer as well as trimethylol propane tri methacrylate (TMPTMA) and ethylene glycol dimethacrylate (EGDMA) as cross linkers respectively and benzoyl peroxide as initiator. The same composition was used in the preparation of non-imprinted polymers (NIPs), but without the template (Phenylephrine hydrochloride). For the preparation of membranes, different plasticizers were used in the PVC matrix, such as Dioctyl phthalate (DOPH), dibutyl phthalate (DBPH), and nitrobenzene (NB). The characteristics studied are the slop, detection limit, lifetime, and linearity range of PPH–MIPs electrodes. Results obtained from selectivity measurements on interfering cations (K+, Ca+2, Al+3) and some pharmaceutical additives such as methylparaben, propylparaben, trisodium citrate showed no interfering with drug phenylephrine hydrochloride. The preparation electrodes have been shown good response including testing pharmaceutical analysis.