Abstract
Background: The utilization of nanoparticle systems presents a promising means for enhancing the efficacy of specific therapeutic interventions, particularly in topical applications. One of the nanoparticle systems that possesses several advantages is the nanostructured lipid carrier (NLC). It is comprised of solid and liquid lipids that form a lipid matrix with the addition of a surfactant. The utilization of lipids in NLC could impact various physical characteristics and drug release. Objective: This study aims to ascertain the considerations involved in selecting solid and liquid lipids. Method: The research approach to be undertaken is a systematic literature review, which refers to an investigation conducted through the process of identifying, evaluating, and interpreting all pertinent findings related to a study, topic, or phenomenon associated with NLC. Results: the obtained results reveal that various NLC-related articles indicate that polymorphism, the solubility of active compounds, and the ratio of solid and liquid lipids may exert a significant influence on the physical characteristics and release of active compounds. Conclusion: Consideration of the choice between solid and liquid lipids can be made to optimize topical therapeutic efficacy.
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