Abstract
Metal-organic frameworks (MOFs) have garnered significant attention in the field of cancer drug delivery owing to their porosity, high drug-loading capacity, and large surface area. In our recent research, we synthesized a redox-responsive MOF using zirconium (Zr) as the metal ion and 4,4-dithiobisbenzoic acid (DTBA) as the organic linker. The synthesis method employed was the hydrothermal method, and it was observed that the MOF synthesized at 400°C had a particle size of less than 200 nm and a zeta potential of +35 mV, indicating its suitability as a carrier for drug delivery. Chrysin, a natural anticancer drug, was used in this study. Glutathione, which is abundantly present in tumor cells, cleaves the disulfide bond in the organic ligand (DTBA), leading to faster drug release. By incorporating chrysin into the synthesized MOF, we observed faster in vitro drug release, with 88 and 89% at pH 7.4 and 5.5, respectively. The synthesis of ZrDTBA MOF opens up new opportunities for its application in drug delivery.
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