Relationship between anti-cyclic Citrullinated petide antibody and cardiovascular complication associated with rheumatoid arthritis

Abstract

Objective The aim of this study was to assess the relationship between the level of anti-CCP antibody and cardiovascular(CV) risk in rheumatoid arthritis(RA) patients.Methods A total of 78 RA patients were enrolled in the study.They were divided into two groups:40 cases with CV comphtations which were secondary from RA and 38 cases with no complications.The anti-CCP antibody was diagnosed by enzyme - linked immunoabsorbent assay(ELISA) and rheumatoid factor(RF) were assessed by immunoturbidimetry method.The relationship between the levels of the two sera auto-antibodies and CV disease associated with RA was analyzed.Results The results showed that the level of anti-CCP antibody in RA-CV disease group was significantly higher than that in simple RA group(74.6％ VS 87.3％ ).Compared with the simple RA group,the level of anti-CCP antibody in the RA-CV disease group was higher,and with significant difference between the two groups( x2 =5.07,9.04,6.48,all P ＜ 0.05 ).RF positive rate was 95.8％ of the patients with RA-CV disease while it was 76.5％ in simple RA group,and the difference between the two groups was statistically significant( x2 =33.41,26.05,34.14,all P ＜ 0.05 ).The morbidi ty between the different level of RF had remarkable difference.In RA patients with CV complations,we compared antiCCP antibody and RF by Spearman analysis,whish showed no relationship between them ( r =0.301,P =0.174 ).Conclusion The results indicated that CV disease secondary from RA was more common in old patients.In RA patients the high level of anti-CCP antibody and RF maybe play an important role in the appearance of CV disease. Key words: Anti-cyclic citrullinated peptide antibody; Arthritis,rheumatoid; Cardiovascular complications