Correlation study of Eotaxin-1, RF and anti-CCP antibody with disease activity of rheumatoid arthritis patients

Abstract

Objective To study the relationship between the disease activity and Eotaxin-1, rheumatoid factor (RF) and anti-cyclic cirullinated peptide (anti-CCP) antibody in patients with rheumatoid arthritis(RA). Methods Total of 52 RA patients treated from April 2017 to April 2018 in The Central Hospital Of Enshi Autonomous Prefecture were selected as RA group, and 46 non-RA patients were selected as non-RA group.At the same time, 50 healthy check-ups were selected as control group.Serum RF, Eotaxin-1 and anti-CCP antibody levels were detected to analyze its correlation with disease activity. Results The antibody levels of serum Eotaxin-1, RF and anti-CCP were significantly different among the RA group, non-RA and control groups (F values were 22.91, 365.07 and 565.68 respectively, all P values<0.05). The expression levels of Eotaxin-1, RF and anti-CCP antibody in RA group were higher than those of non-RA group and control group, and the RF and anti-CCP antibody in non-RA group were higher than those of control group.There was no significant difference in serum Eotaxin-1 level between non-RA group and control group.Serum Eotaxin-1 level was positively correlated with the number of swollen joint count(SJC), tender joint count (TJC) and disease activity score (DAS28)(r values were 0.486, 0.512 and 0.802 respectively, all P values <0.05). RF antibody levels were positively correlated with DAS28(r=0.264, P<0.05). The anti-CCP antibody levels were positively correlated with TJC and DAS28(r values were 0.258 and 0.479, both P values <0.05). Conclusion Monitoring Eotaxin-1 and anti-CCP antibody levels are of great importance to clinical prognosis and treatment, which may be considered as a new serological indicator in the disease activity of RA patients. Key words: Rheumatoid arthritis; Disease activity; Eotaxin-1; Rheumatoid factor; Anti-cyclic cirullinated peptide antibody