Abstract
The purpose of the study was to assess the efficacy of single photon emission computed tomography (SPECT) with 199Tl and 99mTc-MIBI in the detection of breast, laryngeal and hypopharyngeal cancers. Materials and Methods: a total of 220 patients were included into the study. Of them, there were 120 patients with breast lesions (100 patients with breast cancer and 20 patients with benign breast tumors) and '00 patients with laryngeal/hypopharyngeal diseases (80 patients with laryngeal/hypopharyngeal cancer and 20 patients with benign laryngeal/hypopharyngeal lesions). Results: no abnormal 199Tl uptake was seen in all patients with benign breast and laryngeal lesions, indicating a 100% specificity of 199Tl SPECT. In breast cancer patients, increased 199Tl uptake in the breast was visualized in 94.8% patients, 99mTc-MIBI in 93.4% patients. Increased 199Tl uptake in axillary lymph nodes was detected in 60% patients and 99mTc-MIBI in 93.1% patients. In patients with laryngeal/hypopharyngeal cancer, sensitivity of SPECT with 199Tl and 99mTc-MIBI were 95%. The 199Tl SPECT sensitivity in identification of regional lymph node metastases in patients with laryngeal/hypopharyngeal cancer was 75% and the 99mTc-MIBI SPECT sensitivity was 17%. Conclusion: the data obtained show that SPECT with 199Tl and 99mTc-MIBI can be used as one of the additional imaging methods in detection of tumors.
Highlights
According to the recent WHO data more than 10 million newly diagnosed cancer cases occur annually in the world
The search for radiopharmaceuticals characterized by a high specificity while maintaining adequate sensitivity is of great importance
The aim of our study was to evaluate the efficacy of single photon emission computed tomography (SPECT) with 199Ɍl in the detection of breast and laryngeal/hypopharyngeal carcinomas
Summary
According to the recent WHO data more than 10 million newly diagnosed cancer cases occur annually in the world. In many countries cancer ranks the second most common cause of death following cardiovascular diseases 0. Nuclear medicine techniques have the advantage over X-ray or magnetic resonance imaging in terms of higher specificity with a similar high sensitivity for cancer detection [1,2,3]. The use of nuclear medicine imaging in detection of laryngeal/hypopharyngeal tumors allows prevention of unnecessary diagnostic invasive procedures. 99mTɫ-methoxy-isobutyl-isonitrile (99mTc-MIBI) is the most widely used single photon emission computed tomography (SPECT) tracer in detecting malignant disease [4, 5]. This tracer with a relatively high sensitivity has rather a low specificity. The search for radiopharmaceuticals characterized by a high specificity while maintaining adequate sensitivity is of great importance
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