Potency ratio of domestic and imported propofol in anesthesia of painless artificial abortion

Abstract

Objective To evaluate the clinical anesthesia effects and market price distinction between domestic propofol and imported propofol ( Limengxin / Diprivan).Methods Sixty patients undergoing painless artificial abortion were randomly divided into two groups:Limengxin group (group L) and Diprivan group (group D),30 cases for each group.The two groups received intravenous infusion of sufentanil at 0.1 μg/kg. The patients received propofol (group L:1％ Limengxin and group D:1％ Diprivan) by target controlled infusion (TCI) at a target effect site concentration(Ce) of 4 μg/ml.The surgery began when BIS ＜ 60,and it was needed to maintain BIS 40-60.During the operations,Bp,ECG,SpO2 and BIS were continuously monitored.OAA/S was made to patients every 60 seconds,and operation time,propofol dosage,propofol TCI time,onset time,arousal time and arousal BIS value,instructions response time,BIS ＞ 70 time,awareness in operation,amnesia,various complications and adverse effects were recorded.Results The mBP was decreased after anesthesia in both groups at 1 minute after the start of propofol TCI and when the operations began.The HR presented decrease tendency.BIS was significantly decreased (P ＜ 0.05 ) until to the operations ended,and it was increased after the patients awaked,but it was lower than that before anesthesia.There were no significant difference in BIS and BP between the two groups (P ＞ 0.05 ).There were no significant difference in operation time,propofol dosage,medication time,onset time,arousal time and arousal BIS value,instructions response time,BIS ＞ 70time between the two groups ( P ＞ 0.05).There were also no significant difference in the rank of anesthesia effects and the state of infusion pains between the two groups (P ＞ 0.05).The incidence rate of respiratory depression (6:2) and breathing holding (6:1) in group D was higher than that in group L.There was one patient who had postoperative amnesia in group D. The price of importedpropofol was 1.2 times that of domestic propofol.Conclusions There were no significant difference in anesthesia effects and safeve between domestic propofol and imported propofol (Limengxin / Diprivan)when they were used in the anesthesia of painless artificial abortion. Key words: Drug delivery systems ; Propofol ; Electroencephalography ; Artificial abortion