Abstract
ABSTRACT Bruguiera gymnorhiza (Rhizophoraceae) is an indigenous mangrove plant with a salient history of traditional uses. This study aimed to explore the phytoconstituents and biological responses of its methanolic (95%) leaf extract (ME). The initial phytochemical screening indicated the presence of alkaloids, carbohydrates, saponins, phenols, and flavonoids. Then, the anthelmintic and antioxidant capabilities were evaluated against Pheretima posthuma (earthworms), DPPH (0.004%), and ABTS cation radical solutions, respectively. Afterward, cardioprotective and hepatoprotective responses were studied in cyclophosphamide-induced myocardial damage and paracetamol-intoxicated liver cirrhosis. The anthelmintic study revealed that ME (50 mg mL−1) had a lower potency (7.45 min) than albendazole (3.63 min) in killing parasites. Furthermore, it exhibited a dose-dependent efficacy (IC50 50.297 and 55.126 µg mL−1) against free radicals in both DPPH and ABTS assay, although less effective than the ascorbic acid (IC50 24.177 and 23.61 µg mL−1). The elevated serum levels of cardiotoxicity indicators (aspartate aminotransferase, lactate dehydrogenase, creatine kinase, troponin-I, and lipid profiles) declined by the extract (300 mg kg−1 body weight). Moreover, at a similar dose, it reduced the high circulatory biomarkers (alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase, and total bilirubin) levels of hepatocyte injury. This study recommends promising pharmacological values of Bruguiera gymnorhiza ME.
Published Version
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