Abstract
ABSTRACT Myrsine umbellata, a native Brazilian tree, was investigated for its chemical composition and bioactivity. A total of 44 compounds were identified, including resorcinol derivatives, sesquiterpenes, and embelin. The ethyl acetate leaf fraction exhibited the highest phenolic and flavonoid content, with superior antioxidant activity (IC50 = 8.87–17.33 µg mL-¹) compared to Ginkgo biloba. Specific fractions (MSA, MSH, MSC) showed selective cytotoxicity against melanoma cells (IC50 = 9.51–24.95 µg mL-¹), sparing normal cells. Quercitrin and embelin exhibited low toxicity. These findings suggest M. umbellata as a promising source of natural antioxidants, antimelanogenic agents, and potential chemotherapeutics for pharmaceutical and cosmetic applications.
Published Version
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