Abstract
The purpose of our present study was to evaluate the neuropharmacological activities of the methanolic extract of Dioscorea alata tuber using mice model. Neuropharmacological activities of this extract were determined using standard behavioral mice models like- elevated plus maze and hole board test for anxiolytic activity; open field, hole cross, tail suspension and force swimming test for exploratory activities of mice. Our result showed that D. alata extract possesses significant dose dependent indicative of neophilia in elevated plus maze and hole board test. The time spent in open arm was 28±0.95 seconds (for 250 mg/kg extract feeding group) and 82±2.02 seconds (for 500 mg/kg extract feeding group); whereas the control groups spent time was 19.0±2.17 seconds. In addition, the crude also showed a significant dose dependent suppression of exploratory activity by decreasing serotonin level of swiss albino mice in open field, hole cross, tail suspension and force swimming test respectively at both doses (p
Published Version
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