Evaluation of central nervous system (CNS) depressant activity of methanolic extract of Commelina diffusa Burm. in mice

Tania Sultana,Md Abdul Mannan,Tajnin Ahmed

doi:10.1186/s40816-018-0063-1

Tania Sultana, Md Abdul Mannan + Show 1 more

Open Access

https://doi.org/10.1186/s40816-018-0063-1

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Journal: Clinical Phytoscience	Publication Date: Jan 29, 2018
Citations: 14	License type: open-access

Affiliation: Stamford University Bangladesh

Abstract

BackgroundCommelina diffusa Burm. (Family: Commelinaceae) is usually known as “climbing dayflower or spreading dayflower” in Bangladesh. The plant is used in fever, malaria, insect, bug bites, rheumatoid arthritis, gonorrhea, influenza, and bladder infection etc. The present investigation was undertaken which deals with the evaluation of central nervous system (CNS) depressant activity of methanolic extract of C. diffusa in mice models.MethodsThe central nervous system (CNS) depressant activity of C. diffusa was evaluated by the classical models of depression as open field, hole cross, forced swimming, tail suspension, and thiopental sodium induced sleeping time tests in mice. The animals were divided into control, positive control, and three test groups containing five mice each. The test groups received extract at the doses of 50, 100, and 200 mg/kg body weight orally where as the control group received distilled water (0.1 mL/mouse, p.o.). Diazepam (1 mg/kg, i.p.) was used as standard drug.ResultsIt is clear that the plant extract significantly decreased the locomotor activity of mice in open field and hole cross tests when compared to the control (p < 0.05). It is observed that the extract showed significantly (p < 0.05) increased in immobility time in forced swimming and tail suspension tests in mice. In addition, the extract produced prolongs the sleeping time with onset of action in contrast to the control group.ConclusionsThe present work depicts the evaluation of possible CNS depressant activity of C. diffusa in mice models. The obtained results provide support for the use of this species in traditional medicine and warrants further pharmacological investigations that could lead to novel leads in future.

Highlights

Commelina diffusa Burm. (Family: Commelinaceae) is usually known as “climbing dayflower or spreading dayflower” in Bangladesh
Phytochemical screening Phytochemical screening of the methanolic extract of C. diffusa revealed the presence of alkaloids, flavonoids, saponins, tannins, cardiac glycosides, terpenoids, and steroids (Table 1)
Our results demonstrate a relationship between the central nervous system (CNS) depressant effect of C. diffusa and diazepam which could be suggested in this test

Summary

Introduction

Commelina diffusa Burm. (Family: Commelinaceae) is usually known as “climbing dayflower or spreading dayflower” in Bangladesh. The present investigation was undertaken which deals with the evaluation of central nervous system (CNS) depressant activity of methanolic extract of C. diffusa in mice models. According to WHO estimated, 121 million people suffer from clinical depression [5]. It occurs usually in the early adult life of patients with decrease in monoamine neurotransmitters [6]. Medicinal plants therapies may be effective alternatives in the treatment of depression. Traditional medicine is being re-evaluated by extensive research on different plant species and their active therapeutic principles in worldwide. The rich wealth of plant kingdom can represent a novel source of newer compounds with significant therapeutic activities. The most important merits of herbal medicine seem to be their perceived efficacy, low adverse effects, and low cost [8]

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