Abstract
The incidence of mastitis is directly related to changes in the composition, magnitude, and efficiency of the mammary gland defense system. Mammary gland defense involves a complex system of both innate and acquired immune factors that are based, in part, on various leukocyte populations. Effective defense of the mammary gland, however, also involves nonimmune cell populations that play an important role in sensing the presence of bacteria in the mammary gland. The development of innovative strategies that can enhance otherwise impaired mammary gland defense mechanisms during periods of increased disease susceptibility could have a major impact on the incidence of mastitis. The challenge that confronts researchers now is to gain a better understanding of the complex interactions between the pathogenesis of bacteria, host responses needed to eliminate the pathogens from the mammary gland, and methods to enhance the immune potential of these factors before disease is established.
Published Version
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