Lipid disorders in HIV patients: what about raised HDL-cholesterol?

Satyajit Das

doi:10.15761/bhc.1000150

Abstract

Lipid disorders in HIV patients: what about raised HDL-cholesterol?

Highlights

These studies raised questions about the protective effect of high-density lipoprotein cholesterol (HDL-C) at extreme levels either very low or very high
The algorithms which assess the risk of cardiovascular disease, like Framingham Risk Calculation or Q-Risk Calculation, all use total cholesterol and HDL (TC/HDL) ratio and patients with abnormally raised total cholesterol along with raised HDL-C may give a total TC/HDL ratio within the normal range
It is important that we have understanding about the magnitude of problem HIV patients have with abnormally high HDL-C level and underlying any risk factor associated with that

Summary

Introduction

These studies raised questions about the protective effect of HDL-C at extreme levels either very low or very high. The plasma level of HDL-C may not reflect the actual function of HDL-C. There are several different types of HDL-C and depends upon their cholesterol content and the size of the HDL cholesterol (Figure 2). There has been debate throughout on the ability of HDL-C to have its function when the cholesterol content within the particle is high or low.

Results

Conclusion