Abstract
Cardiotoxicity induced by antineoplastic drug Daunorubicin and its amelioration: A review of literature
Highlights
Anthracycline is a type of antibiotic that comes from Streptomyces peucetius bacteria
DNR-gonadotropin-releasing hormone (GnRH)-based conjugates have no cytotoxic effect on cardiomyocytes
DNR – cardiac myosin interaction is the particular mode of inducing daunorubicin cardiotoxicity
Summary
Anthracycline is a type of antibiotic that comes from Streptomyces peucetius bacteria. All these effects caused down-regulation of cytokines and stem cell markers which reflected impaired chemotaxis, migration and homing of stem cells; and tissue repair in the heart in sub-chronic but not acute model of DAU cardiomyopathy [10]. Myocardial cells were used to investigate the dose and time-dependent cellular enzyme release induced by either Adriamycin or DNR primary cultures in rat.
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