Abstract
Isolated non-autoimmune neutropenia revealing primary hypothyroidism
Highlights
ConclusionIsolated and non-autoimmune neutropenia indicative of hypothyroidism is exceptional and unusual representing a real diagnostic challenge for clinicians
It is recommended to screen for thyroid dysfunction in front of any leucopenia that does not prove itself
Hematological manifestations of hypothyroidism are by far dominated by anemia [12,13] and pancytopenia [14,15]
Summary
Isolated leucopenia/neutropenia indicative of hypothyroidism is very rare and unusual representing a real diagnostic challenge for clinicians. Non-autoimmune forms related to a direct effect of thyroid hormone deficiency are exceptional and respond favorably to treatment with thyroxine. Their knowledge by all health practitioners is necessary to avoid diagnostic delays and costly and often unnecessary investigations. Hypothyroidism should be considered in the differential diagnosis of neutropenia and it is recommended to screen for thyroid dysfunction in front of any leukopenia that does not prove itself
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