Influence of early treatment of pregnancy combined with subclinical hypothyroidism on pregnancy outcome

Abstract

Objective To analyze the influence of early treatment of pregnancy combined with subclinical hypothyroidism (SCH) during pregnancy on pregnancy outcome. Methods From January 2013 to June 2015, 128 pregnant women who were diagnosed as SCH in the Maternal and Child Health Hospital of Beilun District were randomly divided into the observation group and control group according to the digital table, with 64 cases in each group.The observation group was given levothyroxine early treatment, while the control group adopted conventional hospitalization, unexposed.Pregnancy outcomes of the two groups were analyzed. Results After treatment, the incidence rates of complications in the observation group: preeclampsia (4.69%), poor fetal growth (1.56%), premature rupture of membranes (7.81%), less amniotic fluid volume (4.69%), placental abruption (0%), postpartum hemorrhage (3.12%); the incidence rates of complications in the control group: preeclampsia (17.19%), poor fetal growth (10.94%), premature rupture of membranes (21.88%), less amniotic fluid volume (15.63%), placental abruption (6.25%), postpartum hemorrhage (12.50%), and there were statistically significant differences between two groups (χ2=5.133, 4.800, 5.006, 4.195, 4.129, 3.905, P=0.023, 0.028, 0.025, 0.041, 0.042.0.048). After treatment, the incidence rates of adverse pregnancy outcomes: preterm birth (3.12%), cesarean section(60.94%), abortion(0.00%), fetal distress(4.69%), perinatal death (0.00%); the incidence rates of adverse pregnancy outcomes in the control group: preterm birth(12.50%), cesarean section (79.69%), abortion (7.81%), fetal distress (15.63%), perinatal death (6.25%), and the differences between the two groups were statistically significant (χ2=3.905, 5.389, 5.203, 4.195, 4.129, P=0.048, 0.020, 0.023, 0.041, 0.042). Conclusion Pregnancy complicated with SCH has different degree influence on patients with obstetric complications and outcome of pregnancy, early effective drug treatment can significantly reduce the incidence of obstetric complications and adverse pregnancy outcomes. Key words: Pregnancy; Hypothyroidism, subclinical; L-thyroxine; Pregnancy outcome; Cesarean delivery; Prematue rupture of memmbranes