Effect of acute chorioamnionitis on pregnancy outcome in high risk pregnancy

Abstract

Objective To investigate the effect of acute chorioamnionitis on pregnancy outcomes in high-risk pregnancies. Methods A total of 50 high-risk pregnant women with acute chorioamnionitis admitted from Oct 2015 to Oct 2017 were selected as the acute chorioamnionitis group. At the same time, 100 high-risk pregnant women with non-acute chorioamnionitis were selected as the control group. The pregnancy outcome, neonatal complications incidence and fatality rate of the two groups were compared and the death process was recorded. Results The incidences of complication in the acute chorioamnionitis group were cesarean section (56%), preterm delivery (32%), premature rupture of membranes (20%), placental abruption (26%), placenta previa (28%), post partum bleeding (32%), polyhydramnios (20%) and puerperal infection (30%), which were significantly higher than those in the control group (33%, 17%, 2%, 1%, 4%, 7%, 3%, 9%). The overall complication rate (62%) and fatality rate (22%) were significantly higher than those in the control group (11%, 5%), the differences were significant (P<0.05). Three cases died before cesarean section in acute chorioamnionitis group, 8 cases died after childbirth, and the birth weight of the neonated was lighter. In the control group, 2 cases died before cesarean section, 3 cases had postpartum death, and the birth weight was lighter; the causes of neonatal death in both groups were mostly severe asphyxia, anemia, ARDS, DIC, infection and sepsis, etc. Conclusions Acute chorioamnionitis in high-risk pregnancies has severe impact on pregnancy outcomes and is an important cause of neonatal death. Key words: High-risk pregnancy; Acute chorioamnionitis; Cesarean section; Pregnancy outcome