Effects of intervention of thyroid hormones on pregnancy outcomes of women with hypothyroidism during pregnancy

Abstract

Objective To investigate the effects of intervention of thyroid hormones on pregnancy outcomes in women with hypothyroidism during pregnancy. Methods A total of 286 patients with hypothyroidism during pregnancy who were hospitalized by Yangmei Group General Hospital from April 2016 to April 2018 were selected as research subjects. By throwing dice, patients threw even numbers were included in study group (n=143) while patients threw odd numbers were included in control group (n=143). Patients in control group were given conventional iodine supplementation. Patients in observation group were given thyroid hormone therapy based on the treatment of control group. The treatment effects were compared between the two groups, and the effects on pregnancy outcomes, neonatal condition, incidence of pregnancy complications and levels of thyroid hormones were analyzed. Results The incidences of premature delivery, abortion, cesarean section, premature rupture of membranes and placental abruption in study group were significantly lower than those in control group (P<0.05). Thyroid stimulating hormone (TSH) levels in both groups were significantly decreased, while levels of free triiodothyronine (FT3) and free thyroxine (FT4) were increased after treatment (P<0.05). TSH levels in study group were lower than those in control group, while levels of FT3 and FT4 were higher than those in control group after treatment (P<0.05). The incidence of fetal distress and low body weight, and neonatal Apgar score in study group were significantly lower than those in control group (P<0.05). The incidences of complications such as gestational hypertension, gestational diabetes, oligohydramnios and abnormal fetal position in study group were significantly lower than those in control group (P<0.05). Conclusions The effects of thyroid hormones are relatively better in pregnant women with hypothyroidism during pregnancy. Thyroid hormones intervention can significantly improve the thyroid function and neonatal condition, and reduce the incidence of adverse pregnancy outcomes and complications. Key words: Thyroid hormone; Hypothyroidism; Pregnancy outcome