Influence of hypothyroidism during pregnancy on pregnancy outcomes

Abstract

Objective To investigate the influence of hypothyroidism during pregnancy on pregnancy outcome. Methods From January 2016 to January 2018, 1 000 prenatal pregnant women in the People's Hospital of Yuhuan were selected, who accepted thyroid function screening during pregnancy. A total of 92 cases of hypothyroidism during pregnancy were found(hypothyroidism group), among them, 62 pregnant women accepted standard hypothyroidism therapy in time(hypothyroidism treated group), and 30 pregnant women who were close to full-term pregnancy and did not receive normative hypothyroidism therapy (hypothyroid untreated group). Other 908 pregnant women without hypothyroidism were classified as control group. The incidence rates of various adverse pregnancy outcomes between hypothyroidism group and control group were compared, and the incidence rates of various adverse pregnancy outcomes between hypothyroidism treated group and hypothyroid untreated group were compared. Results (1)The incidence rates of gestational hypertension, gestational diabetes mellitus and spontaneous abortion in the hypothyroidism group were higher than those in the control group(16.30% vs. 2.75%, 14.13% vs. 3.08%, 13.04% vs. 2.97%)(χ2=39.947, 26.497, 22.602, P=0.000, 0.000, 0.000). (2)The incidence rates of hypertensive disorder complicating pregnancy, gestational diabetes mellitus and spontaneous abortion in the hypothyroidism treated group were lower than those in the hypothyroidism untreated group(9.68% vs. 33.33%, 8.06% vs. 26.67%, 8.06% vs. 23.33%)(χ2=5.692, 5.766, 4.156, P=0.000, 0.000, 0.000). Conclusion Hypothyroidism in pregnancy has adverse effects on pregnancy outcome. Hypertensive disorders in pregnancy, gestational diabetes mellitus and spontaneous abortion are common. Exogenous thyroxine supplementation can improve pregnancy outcome to a certain extent. Key words: Pregnancy; Hypothyroidism; Pregnancy outcome; Hypertension, pregnancy-induced; Diabetes, gestational; Abortion, spontaneous; Thyroxine