Influence of atorvastatin combined with Quick Heart-Reliever Pill on blood fat and serum inflammatory factors of elderly patients with coronary artery disease

Abstract

Objective To investigate the effect of atorvastatin combined with Quick Heart-Reliever Pill on blood fat and serum inflammatory factors of elderly patients with coronary artery disease. Methods 184 elderly patients with coronary artery disease were selected, and they were randomly divided into control group and observation group according to the digital table, 92 cases in each group.The control group was given atorvastatin treatment, while the observation group was given atorvastatin combined with Quick Heart-Reliever Pill.The levels of serum inflammatory factors(TNF-α, CRP, MMP-9 and IL-6) and blood lipid(TC, TG, HDL-C, LDL-C) in the two groups after 1 month treatment were compared. Results After 1 month treatment, the blood lipid levels(TC, TG, HDL-C, LDL-C) of the observation group were significantly lower than those of the control group[(4.26±0.68)mmoL/L vs.(5.14±0.61)mmoL/L, (1.51±0.17)mmoL/L vs.(1.75±0.19)mmoL/L, (1.60±0.38)mmoL/L vs.(1.52±0.43)mmoL/L, (3.01±0.32)mmoL/L vs.(3.18±0.42)mmoL/L, t=2.774, 2.355, 1.976, 2.476, all P<0.05], and the levels of serum inflammatory factors(TNF-α, CRP, MMP-9 and IL-6) of the observation group were significantly lower than those of the control group[(50.35±7.47)ng/L vs.(64.83±8.96)ng/L, (46.50±5.93)mg/L vs.(57.77±6.48)mg/L, (35.44±6.17)μg/L vs.(46.85±7.44)μg/L, (16.84±6.72)ng/L vs.(26.85±9.42)ng/L, t=11.905, 12.306, 22.159, 8.297, all P<0.05]. Conclusion Atorvastatin combined with Quick Heart-Reliever Pill in the treatment of elderly patients with coronary heart disease can achieve notable effects without increasing the liver burden, which can also effectively refine the blood lipid in patients, reduce the inflammatory factors levels, and it is worthy of clinical promotion. Key words: Coronary artery disease; Atorvastatin; Quick-acting kyushin pills; Aged