Abstract
Babesia divergens causes significant morbidity and mortality in cattle and splenectomized or immunocompromised individuals. Here, we present a 10.7-Mb high-quality draft genome of this parasite close to chromosome resolution that will enable comparative genome analyses and synteny studies among related parasites.
Highlights
Babesia divergens causes significant morbidity and mortality in cattle and splenectomized or immunocompromised individuals
Erythrocytic invasion is a critical component of the B. divergens asexual life cycle, ensuring continual parasite replication in red blood cells (RBCs) [4] and producing a malaria-like disease
A better understanding of the species’ biology and host-parasite interactions may lead to improved control mechanisms and new trends in vaccine and antibabesial drug development
Summary
Babesia divergens causes significant morbidity and mortality in cattle and splenectomized or immunocompromised individuals. Babesia divergens is a tick-borne, intraerythrocytic apicomplexan parasite that causes severe hemolytic anemia in cattle and recently has become a significant zoonotic human pathogen [1]. Erythrocytic invasion is a critical component of the B. divergens asexual life cycle, ensuring continual parasite replication in red blood cells (RBCs) [4] and producing a malaria-like disease. We sequenced the genome of B. divergens human isolate (Rouen 1987) combining three different sequencing platforms to produce a high-quality draft genome.
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