Abstract
Persistent methicillin-resistant Staphylococcus aureus (MRSA) bacteremia (positive blood cultures after ≥7 days) represents a challenging subset of invasive MRSA infections. The comparison of genome sequences of persistent (300-169) and resolving (301-188) MRSA bacteremia isolates with similar genetic background (sequence type 45 [ST45]) will help us to better understand underlying mechanisms of persistent MRSA bacteremia.
Highlights
Persistent methicillin-resistant Staphylococcus aureus (MRSA) bacteremia represents a challenging subset of invasive MRSA infections
The reasons why some MRSA bacteremia strains persist while others resolve during antimicrobial therapy despite similar clinical and microbiologic characteristics are not well understood
We report the complete genome sequences of PB and resolving MRSA bacteremia (RB; negative blood cultures after 2 to 4 days of therapy) clinical isolates with similar genetic background which originated from a multinational S. aureus bacteremia clinical trial collection [2]
Summary
Persistent methicillin-resistant Staphylococcus aureus (MRSA) bacteremia (positive blood cultures after >7 days) represents a challenging subset of invasive MRSA infections. Persistent methicillin-resistant Staphylococcus aureus (MRSA) bacteremia (PB) (positive blood cultures after Ն7 days) comprises 20 to 30% of all episodes of MRSA bacteremia and is especially relevant to endovascular infections [1]. The reasons why some MRSA bacteremia strains persist while others resolve during antimicrobial therapy despite similar clinical and microbiologic characteristics are not well understood.
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