Abstract
Clostridium strains from six phylogenetic groups, C. botulinum groups I to IV, C. baratii, and C. butyricum, display the capacity to produce botulinum neurotoxin. Here, we present the genome sequence of a C. butyricum isolate, the neurotoxigenic strain 5521, which encodes the type E botulinum neurotoxin.
Highlights
Clostridium strains from six phylogenetic groups, C. botulinum groups I to IV, C. baratii, and C. butyricum, display the capacity to produce botulinum neurotoxin
We present the genome sequence of a neurotoxigenic C. butyricum strain, 5521, isolated from a case of botulism
Of the clostridial species for which complete genome sequences are available, 16S rRNA analyses have suggested that C. butyricum is most closely related to group II Clostridium botulinum, Clostridium acetobutylicum, and Clostridium beijerinckii [3]. tblastx comparisons indicate that 2,352, 1,809, and 2,568 genes or pseudogenes of C. butyricum 5521 have orthologs within the genomes of C. botulinum E3 strain Alaska E43 [5] (Genbank accession no CP001078), C. acetobutylicum ATCC 824 [7], and C. beijerinckii NCIMB 8052 [8], respectively
Summary
Clostridium strains from six phylogenetic groups, C. botulinum groups I to IV, C. baratii, and C. butyricum, display the capacity to produce botulinum neurotoxin. C. butyricum strains are found in a variety of environments and are common human and animal gut commensals. Some C. butyricum strains have been found to cause the paralytic condition botulism [1,2,3,4]. These neurotoxigenic C. butyricum strains harbor an operon encoding the type E botulinum neurotoxin (BoNT/E) likely to have been horizontally acquired [5].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
