Abstract
Southern Indian isolate IND1994/01 of bluetongue virus serotype 2 (BTV-2), from the Orbivirus Reference Collection at the Pirbright Institute (http://www.reoviridae.org/dsRNA_virus_proteins/ReoID/btv-2.htm#IND1994/01), was sequenced. Its genome segment 6 (Seg-6) [encoding VP5(OCP2)] is identical to that of the Indian BTV-1 isolate (IND2003/05), while Seg-5 and Seg-9 are closely related to isolates from South Africa and the United States, respectively.
Highlights
Bluetongue virus (BTV) is the type species of the genus Orbivirus, family Reoviridae [1, 2], that exists as at least 27 distinct serotypes [3, 4]
The BTV particle is icosahedral and nonenveloped and is composed of a three-layered protein capsid surrounding 10 double-stranded RNA genome segments ranging in size from 3,944 to 822 bp
Fullgenome sequence data are available for bluetongue virus serotype 2 (BTV-2) from Taiwan [10], belonging to the major eastern (e) topotype; a reassortant-strain of BTV-2 carrying a western (w) Seg-5 [11]; and five BTV-2(w) isolates [12, 13]
Summary
Bluetongue virus (BTV) is the type species of the genus Orbivirus, family Reoviridae [1, 2], that exists as at least 27 distinct serotypes [3, 4]. The BTV particle is icosahedral and nonenveloped and is composed of a three-layered protein capsid surrounding 10 double-stranded RNA (dsRNA) genome segments ranging in size from 3,944 to 822 bp. The genome segments, identified as segments 1 to 10 (Seg-1 to Seg-10) in order of decreasing size [2], encode 7 structural proteins (VP1 to VP7) and 5 nonstructural proteins (NS1, NS2, NS3/3a, NS4, and NS5) [5,6,7,8,9]. BTV strains from different continents have evolved separately, acquiring multiple point mutations, developing characteristic regional variants/“topotypes” of each genome segment.
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