Evaluation of Lipid Profile in Pregnancy and Patients with Gestational Diabetes Mellitus in North Indian Population

Abstract

Background: Significant alterations in maternal lipid metabolism occur during pregnancy. gestational diabetes mellitus (GDM) is the most commonly seen metabolic disorder during pregnancy. The association between dyslipidemia and GDM is unclear. Methods: The study population was from pregnant women attending the antenatal clinic of Department of Obstetrics and Gynecology, Lok Nayak Hospital, Delhi. Ethical clearance was granted by the ethical committee of the institute. Patients who attended the clinic at or before 28 weeks of gestation and were willing to participate were included in the study and venous sample was taken for lipid profile in fasting state. Lipid levels were compared in GDM and non GDM patients. Findings: Total 936 patients were recruited in the study and out of these 64 patients were diagnosed as GDM. The mean values of total serum cholesterol, triglyceride (TG) and high-density lipoprotein (HDL) cholesterol were 194.89+35.96 mg/dl, 170.96+46.69 mg/dl and 50.1+7.16 mg/dl respectively in all pregnant patients. The levels of total serum cholesterol and triglycerides were significantly higher in patients with GDM than in patients without GDM (p<0.001), whereas the difference in HDL cholesterol was not significant between two groups. Interpretation: Triglyceride levels are raised in all pregnant patients. Total cholesterol and triglyceride levels a significantly raised in GDM patients in comparison to non GDM patients.