Abstract

Objective To discuss the relationship between serum total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) of pregnancy and gestational diabetes mellitus (GDM) and/or macrosomia. Methods A total of 27 152 women who delivered from June, 2013 to November, 2014 in 15 hospitals in Beijing were enrolled and assigned in GDM group (n=5 582) and normal group (n= 21 113) after excluding the exclusion criteria. These women were also grouped as macrosomia group (birth weight ≥4 000 g) (n=2 343) and normal weight (<4 000 g, n=24 352). The correlations between blood lipids of the first trimester and GDM, the difference of blood lipids between GDM and normal pregnancy women were analyzed. The relationship of blood lipids in each trimester and macrosomia and/or GDM was also concerned. Correlation analyses and logistic regression was used to analyze the correlation between GDM and macrosomia. Results A positive correlation was found between GDM and serum TG or TC in the first trimester(OR=1.169, 1.291, 95% CI: 1.036-1.319, 1.201-1.388, all P<0.01), while HDL-C levels appeared reverse correlation with GDM (OR= 0.669, 95%CI: 0.567-0.789, P<0.01). Serum TG concentrationsin GDM group were significantly higher (F=4.220-11.707, P<0.01), while serum HDL-C was significantly lower than that in the normal group (F=-9.22--2.47, P<0.05) throughout pregnancy. The incidence of macrosomia in GDM mothers was higher than normal healthy mothers (10.0% vs 7.8%, χ2=23.418, P<0.01). In the first, second and third trimester, macrosomia mothers had higher TG (t=4.845, 3.707, 5.366, P<0.01), and lower HDL-C (t=- 2.917, - 2.622, - 5.38, P<0.01) than mothers who delivered normal birth weight babies. Conclusions Serum TG and TC in the first trimester have a positive correlation with GDM, while HDL-C levels appear reverse correlation with GDM. Both macrosomia and GDM mothers have higher serum TG and lower HDL-C. Key words: Diabetes mellitus, gestation; Pregnancy; Blood lipid; Macrosomia

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