Correlation of prepregnancy weight and lipid levels of late pregnancy in gestational diabetes melli-tus with neonatal birth weight

Abstract

Objective To investigate the relationship of prepregnancy weight and lipid levels of late pregnancy in gestational diabetes mellitus（GDM）with neonatal birth weight. Methods Fifty-two normal glucose tolerance（NGT）pregnant women（control group）and 52 pregnant women with gestational diabetes mellitus（ GDM group）were chose. Hitachi 7080 automatic biochemical analyzer was used to measure the serum levels of total cholesterol（TC）,triglyceride（TG）,high density lipoprotein cholesterol （HDL-C）,low density lipoprotein cholesterol（LDL-C）and lipoprotein（a）[LP（a）]. At the same time, maternal age,gestational age,body weight before pregnancy and fetal birth weight were recorded in the two groups. Results Prepregnancy weight and the levels of TG and LDL-C were significantly higher in GDM group than those in control group（P 〈0. 01）. Prepregnancy weight and the TG was postively correla-ted with neonatal birth weight（P 〈0. 05）. The LP（a）was negatively correlated with neonatal birth weight （P 〈0. 05）. Conclusions Hyperlipidemia including TG and LDL-C in pregnant women with gestational diabetes mellitus are elevated. Gestational diabetes compared with pregnant women with normal glucose tol-erance,has more serious abnormal lipid metabolism,and it significantly affect the neonatal birth weight. Therefore,it has important clinical significance of controling body weight before pregnancy and monitoring serum lipid levels in pregnancy and the necessary dietary guidance for women with gestational diabetes. Key words: Gestational diabetes mellitus; Prepregnancy weight; Lipid; Neonatal birth weight