Abstract
目的 探讨B型脑钠肽(BNP)在急性呼吸道感染合并心力衰竭(CHF)患者中的变化及对预后的影响.方法 选取262例急性呼吸道感染合并CHF患者(CHF组),其中Ⅱ级68例,Ⅲ级92例,Ⅳ级102例;同期住院的老年急性呼吸道感染但无CHF的患者200例作为对照人群(非CHF组),进行BNP检测及心脏左室射血分数(LVEF)、左室舒张末期内径(LVEDD)监测,对住院1个月后再次入院率及病死率进行分析.结果 非CHF组患者BNP、LVEF、LVEDD分别为(526.12±11.18)pmol/L、(65.67±6.28)%、(37.76±5.59)mm,CHF组为(1 522.03±42.27)pmol/L、(36.62±8.83)%、(52.89±5.22)mm,两组差异有统计学意义(P<0.05);CHFⅢ级与Ⅱ级、Ⅳ级与Ⅱ级在BNP、LVEF、LVEDD等指标差异有统计学意义(P<0.05);CHF患者出院时BNP＜400 pmol/L 183例为低浓度组,BNP≥400 pmol/L 79例为高浓度组,1个月后再次入院率低浓度组为6.57%(12/183),高浓度组为39.24%(31/79),高浓度组病死率5.06%,低浓度无死亡,再次入院率及病死率均差异有统计学意义(P<0.05).结论 BNP的动态变化能较好的预测急性呼吸道感染合并CHF患者的预后。
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