Abstract

Objective To analyze the changes of plasma B-type natriuretic peptide (BNP) and uric acid (UA) in patients with chronic heart failure (CHF) before and after treatment, and to evaluate their correlations with severity and prognosis of heart failure. Methods All 170 cases of patients with CHF were selected as CHF group, and were divded into three subgroups according to cardiac function score by the New York Heart Association(NYHA), with 56 cases in grade Ⅱ subgroup, 90 cases in grade Ⅲ subgroup and 24 cases in grade Ⅳ subgroup; and 30 healthy subjects checked in the same period were selected as control group. The levels of plasma BNP and UA in control group were detected, and the levels of pbsma BNP and UA in CHF group were compared before and after commn anti-heart failure treatment. The correlations between NYHA classifications, ejection fraction and prognosis in chronic heart failure patients were analyzed. Results Levels of BNP and UA in CHF group were significantly higher than those in control group (P<0.05), the correlation analysis showed that with the gradual increase of the levels of Plasma BNP and UA, the cardiac function classification and the degree of heart failure gradually increased, and left ventricale ejection fraction (LVEF) decreased. The patients with high levels of BNP and UA had a high incidence rate of cardiac events, and the clinical prognosis was poor. Conclusions The plasma BNP and UA can be used as the indexes to evaluate the severity of heart failure, and with the increase of the cardiac function classification, they will also increase. The levels of plasma BNP and UA will reduce after improving the heart function, contrarily, LVEF will increase, so that it can evaluate the illness situation of patients objectively, observe the effect of treatment and judge the clinical prognosis. Key words: Chronic heart failure; B-type natriuretic peptide; Uric acid; Cardiac function classification

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