Changes of brain natriuretic peptide and inflammatory factors in heart failure patients with lung infection

Abstract

Objective To investigate the distribution and clinical significance of plasma brain natriuretic peptide and inflammatory factors in patients with heart failure and pulmonary infection. Methods Forty-seven heart failure patierrts with pulmonary infection were randomly selected as observation group, and the plasma levels of brain natriuretic peptide (BNP), interleukin-6 (IL-6) and tumor necrosis factor ( TNF-α) were recorded. Another 40 cases of healthy people were selected as control group, the levels of BNP and inflammatory cytokine of the two groups were analyzed, and the relationship between these indicators and the cardiac function in observation group were investioated. Results Compared with the control group, the levels of BNP, IL-6 and TNF-α of observation group increased in varierd degrees, the differences were significant (P 0), the difference was significant (P<0.05). Conclusions In patients with heart failure and pulmonary infection, the levels of serum BNP, IL-6, TNF-α and other inflammatory factors increased, and there was significant correlation of the indexes with the degree of cardiac dysfunction, the indexes can be used as important basis for clinical diagnosis and prognosis evaluation of such patients. Key words: Heart failure; Pulmonary infection; Plasma brain natriuretic peptide; Inflammatory cytokines; Cardiac function