Abstract
ABSTRACTSalmonella enterica serovar Typhi with reduced susceptibility to ciprofloxacin is increasingly being reported globally. An outbreak caused by Salmonella Typhi with decreased ciprofloxacin susceptibility has not been reported before in Malaysia. We present here the annotated draft genome of a Salmonella Typhi strain involved in a typhoid outbreak.
Highlights
Salmonella enterica serovar Typhi with reduced susceptibility to ciprofloxacin is increasingly being reported globally
The isolate showed a Ser[83] Ͼ Phe mutation in the QRDR of the gyrA gene. This is one of the common point mutations in the gyrA gene that is found to be associated with quinolone resistance (5)
Multilocus sequence typing (MLST) analysis revealed that this strain belongs to sequence type 2 (ST2)
Summary
Salmonella enterica serovar Typhi with reduced susceptibility to ciprofloxacin is increasingly being reported globally. DNA of Salmonella Typhi IMR_TP298/15 was extracted using the Masterpure DNA purification kit (Epicentre, Madison, WI, USA). The DNA library was prepared following the Illumina protocol using the Nextera XT DNA sample prep kit (Illumina, San Diego, CA, USA).
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