Abstract
ABSTRACT The phytochemical composition, anti-oxidant and cytotoxic potential of Simarouba glauca leaf extracts were examined. The anti-oxidant activity was determined by DPPH, PM and FRAP assays. The determination of cell viability was performed by MTT assay. The acetone and methanol extracts showed higher anti-oxidant capacities than other extracts. The methanol and acetone extracts inhibited PA1 ovarian cancer cell growth in a dose-dependent manner with IC50 values 106.67 ± 1.53 μg/ml−1 and 124.43 ± 3.04 μg/ml−1, respectively, compared to the standard drug Doxorubicin (IC50 = 2.91±0.03 μg/ml−1). The selectivity of the plant proved to have a promising anti-cancer potential by inhibiting PA1 ovarian cancer cell lines.
Published Version
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