Abstract
We report the whole-genome sequences of an Escherichia coli laboratory wild-type strain and trimethoprim-resistant strains (two biological replicates, TMP32XR1 and TMP32XR2). Compared to the U00096.3 strain, a widely used strain in laboratory experiments, the laboratory wild-type strain and the drug-resistant strains evolved from this (TMP32XR1 and TMP32XR2) are 13, 24, and 37 bp longer, respectively.
Highlights
We report the whole-genome sequences of an Escherichia coli laboratory wild-type strain and trimethoprim-resistant strains
The laboratory wild-type E. coli was subjected to increasing doses of trimethoprim (TMP), and the TMP resistant strains (TMP32XR1 and TMP32XR2) were selected using standard protocols [4, 5]
A total of 6 insertion and deletions (INDELs) and 2 SNPs were observed in the laboratory wild-type E. coli
Summary
We report the whole-genome sequences of an Escherichia coli laboratory wild-type strain and trimethoprim-resistant strains (two biological replicates, TMP32XR1 and TMP32XR2). Escherichia coli is a Gram-negative coliform bacterium, used widely as a safe laboratory model for a wide range of biological problems. Resistance in E. coli has been reported to be predominantly community-acquired [2].
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