Comparison of the effects of aminophylline and doxofylline in the treatment of bronchial asthma

Abstract

Objective To compare the clinical effects of aminophylline and doxofylline in the treatment of bronchial asthma, thus to provide guidance for clinical practice. Methods 130 patients with bronchial asthma admitted in Zhejiang Rongjun Hospital from January 2015 to January 2017 were selected as the objects of observation, and they were randomly divided into two groups according to the digital table, with 65 cases in each group.The control group was given aminophylline treatment, the observation group was given doxofylline treatment.The clinical curative effect, pulmonary function index[forced vital capacity (FVC), forced expiratory volume in one second(FEV1), FEV1/FVC], quality of life scores and the incidence rate of adverse reactions were observed in the two groups. Results The total effective rate of observation group was 92.31%, which was higher than 70.77% of the control group, the difference was statistically significant(χ2=10.015, P<0.05). After treatment, the FEV1[(2.72±0.64)L], FVC[(2.96±0.67)L], FEV1/FVC[(89.35±7.77)%] in the observation group were significantly better than those in the control group[(2.05±0.35)L, (2.41±0.52)L, (80.58±7.69)%] (t=7.405, 5.228, 6.467, all P<0.05). The quality of life score in the observation group was (87.87±5.31)points, which was significantly higher than (75.35±5.40)points in the control group (t=13.328, P<0.05). The incidence rate of adverse reactions in the observation group was 9.23%, which was lower than 27.69% in the control group, there was statistically significant difference between the two groups(χ2=7.358, P<0.05). Conclusion Aminophylline and doxofylline in the treatment of bronchial asthma can obtain certain curative effect, but the effect of doxofylline is better, and with less adverse reactions. Key words: Asthma; Bronchi; Aminophylline; Doxofylline; Respiratory function tests; Controlled clinical trial