Clinical study of ligustrazine combined with phentolamine in the treatment of pregnancy induced hypertension

Abstract

Objective To investigate the effect of ligustrazine combined with phentolamine in the treatment of pregnancy induced hypertension. Methods 90 patients with pregnancy induced hypertension were randomly divided into the observation group and the control group according to the random number table, 45 cases in each group.The control group was treated with phentolamine and magnesium sulfate.The observation group was given Chuanqiongqin injection, phentolamine and magnesium sulfate for 10 days.The effects of the two groups were compared before and after treatment, and the changes of mean arterial pressure, 24h urine protein and perinatal adverse reaction were compared. Results After treatment, the mean arterial pressure[(99.7±36.2)mmHg vs.(108.4±35.1)mmHg]and 24h urinary protein[(1.41±0.45)g/L vs.(2.51±0.82)g/L]were significantly decreased in the two groups.Compared with before treatment, the differences were statistically significant(t=3.534, 3.765, 5.646, 6.543, all P<0.05). And the improvement of the observation group was significantly better than those of the control group, the differences were statistically significant(t=3.365, 3.986, all P<0.05). The cure rate (71.1% vs.44.4%) and total effective rate(95.6% vs.82.2%) in the observation group were higher than those in the control group, the differences were statistically significant (χ2=6.559, 4.050, all P<0.05). The rate of termination of pregnancy of the observation group was significantly lower than that of the control group(40.0% vs.62.2%), the incidence rates of premature delivery (2.2% vs.15.6%) and postpartum hemorrhage(6.7% vs.22.2%) of the observation group were significantly lower than those of the control group, the proportion of neonatal asphyxia (4.4% vs.17.8%) of the observation group was lower than that of control group, the differences were statistically significant (χ2=4.447, 4.939, 4.406, 4.050, all P<0.05). Conclusion Ligustrazine combined with phentolamine in the treatment of pregnancy induced hypertension can significantly improve the average arterial pressure and 24h urinary protein, has good efficacy, less adverse reactions during perinatal period. Key words: Pregnancy induced hypertension; Ligustrazine; Magnesium Sulfate; Phentolamine