Effects of magnesium sulfate combined with nifedipine on blood pressure and pregnancy outcome in patients with pregnancy-induced hypertension

Abstract

Objective To observe the effects of magnesium sulfate combined with nifedipine on blood pressure and pregnancy outcome in patients with pregnancy-induced hypertension (PIH). Methods A total of 108 PIH patients were selected as the research objects, and were divided into control group and observation group according to random number table method, with 54 cases in each group. The control group was treated with magnesium sulfate, and the observation group was treated with nifedipine on the basis of treatment for control group. The clinical effect, blood pressure before and after treatment, the complications and the outcomes of pregnancy of the two groups were observed. Results The total effective rate of control group (81.48%) was lower than that of observation group (96.30%), the difference was statistically significant (P 0.05); after treatment, SBP and DBP in observation group were higher than those in control group, the difference was statistically significant (P<0.05); the incidences of complication, premature birth, postpartum hemorrhage, fetal distress, low body weight in control group were higher than those in observation group, the difference was statistically significant (P<0.05). Conclusions Magnesium sulfate combined with nifedipine has a good effect in the treatment of PIH, which helps to reduce the blood pressure and incidence of related complications, improve the pregnancy outcome. Key words: Pregnancy-induced hypertension; Magnesium sulfate; Nifedipine; Blood pressure; Pregnancy outcome