Clinical efficacy of comprehensive hyperbaric oxygen on the patients with pregnancy-induced hypertension and on the levels of serum ET-1 and nitric oxide

Abstract

Objective To investigate the clinical efficacy of hyperbaric oxygen (HBO) combined with nifedipine and magnesium sulfate in the treatment of the patients with pregnancy-induced hypertension and its effects on the levels of serum ET-1 and nitric oxide (NO). Methods Ninety-two patients with pregnancy-induced hypertension admitted into the Genital Medical Center of Zhongda Hospital Affiliated to Dongnan University from March 2017 to September 2018 were enrolled for study, and were randomly divided into two groups, the control group and the observation group, each consisting of 46 patients. The patients in the control group were given nifedipine sustained-release tablets and magnesium sulfate injection for reduction of blood pressure, while the patients in the observation group received HBO in addition to the treatment given to the control group. Changes in blood pressure and urine protein levels were closely observed in the patients of the 2 groups. The levels of ET-1 and NO in the patients were detected with ELISA. Statistical analyses were made on inytauterine fetal development delay, inytauterine fetal distress, fetal biological-physical scores (BPS), the ratio of umbilical systolic pressure and diastolic pressure as well as 1-min Apgar scores for the patients of the 2 groups. Results Ten days after treatment, systolic pressure and diastolic pressure in the patients of the 2 groups significantly decreased, with those of the observation group being obviously lower than those of the control group, with statistical significance (P<0.05 or P<0.01). Compared with the urine protein levels before treatment, the urine protein levels in the patients of the 2 groups all significantly decreased, with that of the observation group after treatment [(0.6±0.1) mg/L] being lower than that of the control group [(0.9±0.1) mg/L], also with statistical significance (P<0.05 or P<0.01). After treatment, the serum ET-1 levels in the patients of the 2 groups all decreased, while NO levels elevated (P<0.01). Compared with those of the control group, the serum ET-1 level in the patients of the observation group decreased and NO level elevated, also with statistical significance (P<0.05 or P<0.01). The intrauterine growth retardation, intrauterine distress, BPS, S/D value and 1-min Apgar scores for the observation group were all obviously superior to those of the control group, also with statistical significance (all P<0.05). Conclusion The treatment strategy of HBO combined with nifedipine and magnesium sulfate could produce definite clinical efficacy and it has a significant impact on the expression levels of ET-1 and NO. Key words: Pregnancy hypertension; Hyperbaric oxygen; Nifedipine sustained release tablet; Magnesium sulfate injection; ET-1; Nitric oxide