Abstract
Objective To investigate the therapeutic effect of gangliosides combined with hyperbaric oxygen therapy（ HBO） in treatment of neonatal ischemic encephalopathy （ HIE） .Methods 68 patients with HIE were ran-domly divided into 4 groups（n=17）：the control group,gangliosides group,HBO group and combined group .The con-trol group received conventional therapy ,gangliosides and HBO group received gangliosides and HBO therapy respec-tively and combined group received both gangliosides and HBO therapy .The therapeutic effects were evaluated 10d and 20d after treatment.Results Compared with the control group ,the total efficiency was significantly increased in the combined group（χ2 =5.885,P〈0.05）,but not in gangliosides and HBO group .Moreover,all treatment groups significantly elevated the neonatal behavioral neurological assessment （NBNA）in day 10 and 20,and there were signif-icant differences between the combined group and gangliosides or HBO group （ t=3.755,P〈0.05;t=3.533,P〈0.05）.Conclusion The use of gangliosides combined with HBO has synergistic interaction in treatment of HIE , which is worthy of clinical application . Key words: Hypoxia,Brain; Combined Modality Therapy; Asphyxia Neonatorum
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