Clinical research of mild hypothermia combined with hyperbaric oxygen in the treatment of neonatal hypoxic-ischemic encephalopathy

Abstract

Objective To investigate the clinical effect of mild hypothermia complicated with heperbaric oxygen in the treatment of neonatal hypoxic-ischemic encephalopathy.Methods Seventy-five neonatal hypoxic-ischemic encephalopathy patients were randomly divided into mild hypothermia complicated with heperbaric oxygen group(40 cases) and the control group(35 cases).The newborns in control group were given routine and comprehensive treatment.The newborns in treatment group were given mild hypothermia complicated with heperbaric oxygen therapy on the basis of routine and comprehensive treatment.The newborns with HIE were estimated by neonatal behavioral neurological assessment (NBNA) after being born 4 days and 14 days and were examined by mental and psycho-motor development after being born 3 months,6months and 12 months.Results The NBNA score when the newborns were 4 days had no obvious difference between the two groups (t=0.126,P>0.05).The NBNA score when the newborns were 14 days had obvious difference between the two groups(t=2.48,P<0.05).The index of mental and psychomotor development when the newborns were 3 months,6months and 12 months in mild hypothermia complicated with heperbaric oxygen therapy group was obviously higher than that in control group.There were obvious difference between the two groups(P<0.05).Conclusions Mild hypothermia complicated with heperbaric oxygen therapy have obvious near ang long neurological protective action on neonatal hypoxic-ischemic encephalopathy and can improve the living quality.The treatment effect is positive. Key words: Neonatal hypoxic-ischemic encephalopathy; Mild hypothermia; Hyperbaric oxygen; Asphyxia; Organ injury; Prognosis