Clinical effect of different doses of mifepristone in the treatment of perimenopausal dysfunctional uterine bleeding

Abstract

Objective To analyze the effect and safety of different doses of mifepristone treating perimenopa-usal dysfunctional uterine bleeding.Methods 80 patients with perimenopausal dysfunctional uterine bleeding were collected.According to the medicine of 5,10mg,25mg mg doses,80 cases were divided into the low dose group （n=26）,middle dose group （n=26） and high dose group （n=28）.The treatment results,endometrial thickness change, sex hormone level change and the adverse reaction were observed after 3 months.Results In terms of treatment effect,the effective rate in the middle dose group （92.3%） and high dose group （82.1%） were better than that of the low dose group（61.5%）（F=3.98,P〈0.05）;The inhibitory effect of endometrium in the middle dose group and high dose group were superior to the low dose group（ F=4.34,P〈0.05）;All three groups of sex hormone level was significantly lower in the body;Middle and high dose group of the adverse reactions of treatment process was more,the adverse reaction happening far higher than that of the low dose and dose group （F=3.97,P〈0.05）. Conclusion 10mg mifepristone in the treatment of perimenopausal dysfunctional uterine bleeding has good effect, less adverse reactions,which is worthy of clinical application. Key words: Uterine hemorrhage; Perimenopause; Mifepristone