Abstract
Objective To explore the clinical effect of three doses of mifepristone on patients with dysfunctional uterine bleeding. Methods 150 patients with dysfunctional uterine bleeding were chosen, and they were randomly divided into 3 groups, including low dose group (50 patients), middle dose group (50 patients) and high dose group (50 patients). All patients adopted routine treatment.On the basis of this, the low dose group received 6.25mg/d mifepristone, the middle dose group received 12.5mg/d mifepristone, the high dose group received 18.25mg/d mifepristone, continued 6 months.The influence of follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E), progesterone (P), volume of uterine and endometrail thickness of patients were observed. Results After treatment, the FSH, LH, E and P levels in the three groups were significantly decreased compared with before treatment (FSH: t=4.406, 5.329, 3.610, LH: t=4.563, 6.134, 4.455, P=0.000, 0.000, 0.000; P=0.000, 0.000, 0.000; E: t=7.173, 6.815, 7.018, P=0.000, 0.000, 0.000; E: t=2.367, 6.315, 4.351, P=0.020, 0.000, 0.000), and the difference were statistically significant (all P 0.05). Compared with the low dose group, E levels in the middle dose group and high dose group significantly decreased(t=3.850, 2.085, P=0.000, 0.004). Before and after treatment, the uterine volume among the three groups had no significant difference (P>0.05). After treatment, the functional uterine bleeding symptoms were significantly relieved in the three groups, the effective rate was 100%.The recurrence rate of the low dose group was 32%, which was significantly higher than 8% and 10% of the middle dose group and high dose group.The amenorrhea rate of the middle dose group and high dose group(6% and 2%) was significantly lower than that of the low dose group (46%). Conclusion The treatment of 12.5mg/d mifepristone is effectively adapted to patients with dysfunctional uterine bleeding. Key words: Mifepristone; Uterine bleeding; Dose-respone relationship, drug
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