Comparison of the clinical effect of different doses of rosuvastatin in the treatment of hyperlipidemia and carotid atherosclerotic plaque in young ischemic stroke patients

Abstract

Objective To observe the efficacy and safety of rosuvastatin in the treatment of hyperlipidemia and carotid atherosclerotic plaque in young ischemic stroke patients. Methods In prospective study, 264 young ischemic stroke patients with hyperlipidemia and carotid atherosclerotic plaque were randomly divided into low dose group, middle dose group, high dose group, 88 cases in each group.All patients were given rosuvastatin immediately after dinner, in doses of 5mg, 10mg, 20mg, respectively, for eight months.Then, the changes of hyperlipidemia and carotid atherosclerotic plaque in the three groups were surveyed, and its safety by the observation of clinical symptoms and monitoring of adverse reactions after eight months were assessed. Results Before treatment, the blood fat and carotid atherosclerosis plaque index in the three groups had no statistically significant differences (all P>0.05). After treatment, the total cholesterol, triglycerides, low-density lipoprotein cholesterol of the high dose group were (1.67±0.68)mmol/L, (3.23±0.53)mmol/L, (1.83±0.62)mmol/L, which of the middle dose group were (1.93±0.74)mmol/L, (3.73±0.23)mmol/L, (2.24±0.73)mmol/L, which of the low dose group were (2.16±0.77)mmol/L, (4.06±0.93)mmol/L, (2.93±0.35)mmol/L.These indicators were decreased than before treatment [(2.79±0.72)mmol/L, (5.40±0.67)mmol/L, (3.64±1.03)mmol/L, (2.75±0.81)mmol/L, (5.59±0.95)mmol/L, (3.43±0.92)mmol/L and (2.83±0.53)mmol/L, (5.84±0.79)mmol/L, (3.83±0.88)mmol/L]. The decrease of the high dose group was higher than the middle and low dose group, the difference was statistically significant(F=6.61, P 0.05), and no serious adverse reaction was found. Conclusion The high dose rosuvastatin treatment can reverse the nature of plaque, decrease the thickness of the plaques and lower blood lipid of young ischemic stroke with hyperlipidemia and carotid atherosclerotic plaque, which is better than middle and low dose, and has better security.There is no serious adverse reaction.It is worth for clinical promotion. Key words: Brain ischemic; Hyperlipidemia; Rosuvastatin; Carotid atherosclerosis plaque