Clinical effect of atorvastatin in treatment of coronary heart disease

Abstract

Objective To analyze the clinical effect of atorvastatin combined with conventional cardiovascular drugs therapy in treatment of coronary heart disease. Methods 200 patients with coronary heart disease were collected.They were randomly divided into the observation group(n=100) and control group(n=100). The observation group was given atorvastatin combined with cardiovascular routine treatment for 1 year, the control group was given cardiovascular routine therapy for 1 year.The clinical effect and serum levels of TC, HDL-C, LDL-C were analyzed. Results After treatment, the total effective rate of the observation group was 95%, which was significantly higher than 75% of the control group (χ2=16.33, P=0.00 0.05; HDL-C: (1.35±0.23)mmol/L vs (1.29±0.32)mmol/L, t=1.51, P=0.15>0.05; LDL-C: (4.54±0.62)mmol/L vs (4.48±0.61)mmol/L, t=0.84, P=0.20>0.05]. After treatment, the serum levels of TC, HDL-C, LDL-C of the observation group were significantly better than those of the control group[TC: (3.39±0.31)mmol/L vs (5.78±0.64)mmol/L, t=2.36, P=0.02<0.05; HDL-C: (1.63±0.42)mmol/L vs (1.32±0.51)mmol/L, t=2.87, P=0.00<0.05; LDL-C: (2.37±0.42)mmol/L vs (3.95±0.43)mmol/L, t=2.62, P=0.01<0.05]. Conclusion Atorvastatin can reduce blood fat, improve the prognosis of disease, it is superior to the traditional treatment. Key words: Coronary disease; Atorvastatin; Treatment outcome