Clinical curative effect of salmeterol fluticasone in asthma therapy and its influence on lung function and serum CRP

Abstract

Objective To investigate the clinical curative effect of salmeterol fluticasone asthma and its influence on lung function, serum CRP. Methods 202 cases of asthma patients were divided into the observation group and control group, with 101 cases in each group. The control group patients simply give fluticasone propionate inhalation therapy, the observation group patients were given salmeterol fluticasone inhalation therapy. Before and after treatment in patients with two groups of curative effect and treatment of pulmonary function, the change of serum CRP were compared. Results The total effective rate of the observation group was 92.1%,which was higher than the control group(78.2%)obviously, the difference was statistically significant (χ2=3.842,P<0.05). After treatment, the forced vital capacity(FVC), forced expiratory volume in first second(FEV1)and the maximum peak expiratory flow(PEF)of the observation group were respectively(84.11± 16.25)%,(96.34±19.65)%and(93.14±17.85)%,and the control group were respectively(74.31±14.27)%,(84.36±20.31)%and(83.52±19.89)%,each group was obviously improved than before treatment, and the observation group improvement were better than the control group,the difference was statistically significant(t=3.425,2.573,2.895,all P<0.05).After treatment,the CRP of the observation group was(18.94± 3.46)mg/L, and the control group was(10.34±1.97)mg/L, each group was obviously improved than before treatment, and the observation group improvement was better than the control group,the difference was statistically significant(t=2.874,P<0.05). Conclusion Salmeterol fluticasone inhaled asthma can significantly improve the clinical curative effect to improve the patient's lung function and serum CRP level,and is safe and reliable.It is worth widely application in the clinical practice. Key words: Salmeterol fluticasone; Asthma; Lung function; C reaction protein